cirrhosis

ially when diagnosed early. The first year is critical; effective intervention can slow progression, improve symptoms, and enhance quality of life. Indicators for Specialized Care Patients should consult hepatologists or transplant centers if they experienc

Mechanisms The etiology of PBC remains incompletely understood, but it is widely regarded as an autoimmune disorder triggered by genetic predisposition and environmental factors. Certain HLA alleles, such as HLA-DR8 a

f the skin and eyes caused by impaired bilirubin clearance. 2. Abdominal Distension: Ascites resulting from portal hypertension and 3. hypoalbuminemia. Spider Angiomas and Palmar Erythema: Vascular skin changes linked to 4. hormonal imbalances. Easy Bruising and Bleeding: Du